With PLA 3.0.5 we introduce a new add-on: The Dose-Response Analysis Package provides a range of additional biostatistical methods for immunoassays, ELISA, and more. It supports you in investigating equivalence for calibration curves and it provides enhanced data processing and analysis. New document reports and dashboards add to its value and usability.
The biostatistical methods of the new package include :
The package features several equivalence test and development options for calibration curves. You can employ equivalence and point estimate tests for parameter estimates and ANOVA terms. And you can use your historic assay runs to develop acceptance criteria. The package provides test strategy development, visualizations, and simulations. Read more...
The new package also features enhanced response data processing. You can adjust and normalize data either by a fixed value or by another assay element. Use these features, for example, to subtract the absorbance of blank wells or to divide response values by the mean absorbance of maximum binding wells. You can also employ transformations–logarithmic, square, and square-root. Apply adjustments, normalizations, and transformations to all samples, a specific sample, or to all test or control samples. You can apply adjustments and normalizations to specific plates as well. Moreover, you can average your replicates. To give you full control over data processing, you can employ several adjustment and normalization steps and you can adjust the sequence of response data processing steps to your needs.
With the new package, you can define analysis subgroups suitable to your experiment. Subgroups are available for both, single- and multi-dose samples. Use this feature, for example, to group samples in spike-and-recovery analysis or assay optimization. Statistics for interpolated results and dose-response curve characterization include averages, standard deviations, coefficient of variations, and recovery rates. Visualize results in overlay plots.
New document reports and dashboards further add to the package's value and usability. The dashboards display key attributes of document definitions and calculation results and visualize results in new data plots. The revised design of both reports and dashboards provides greater lucidity with a fresh and modern look, clear, uniformly applied layout, and a uniform color scheme in line with editor. Read more...
PLA 3.0.5 always keeps you informed about new extensions and developments. You can easily customize your work environment to get the most out of your installation.
The new Add-on management enables you to benefit from new extensions and developments. Stay informed on new releases and updates such as document packages and data acquisition modules. The Add-on management provides you with a list that is always up to date and puts all suitable add-ons at your fingertips. Just click once to start the add-on download and installation.
Now you can easily extend your work environment with new features. To evaluate them, simply try and use our latest products and integrated tools. You can request add-on trials and licenses with a single mouse click and activate and deactivate them just as easily. We provide demo data in the same location.
The add-on management also provides options to easily install and work with several add-on versions. Simply activate and try the newest add-on versions, or switch to a legacy version to run your legacy assays. You can update to PLA 3.0.5 to benefit from its innovations and still work with add-on versions that have already been validated in your environment.
The new dashboard keeps you informed about new developments and events around PLA 3.0.5. It also provides information on the database and can provide information posted by your organization. Last but not least, it displays your license and support status and enables all users to get quick access to help and support.
Customers who already work with PLA will notice numerous improvements that enhance performance and usability. Our efforts to improve your experience with PLA have streamlined workflows and eliminated redundant tasks.
When you develop a new assay document, PLA 3.0.5 uses the information you provide to automatically set up the data table. When you work with a plate layout, for example, PLA 3.0.5 now arranges the data table to match your layout as you develop the new assay document. In addition, PLA 3.0.5 enables you to easily adjust your data table to employ alternate plate layouts, accommodate data acquisition, or correct assignment errors.
Other improvements in PLA 3.0.5 further enhance the user experience:
Our new PLA 3.0.5 features.