What's new in PLA 3.0.5

Watch the 'What's New in PLA 3.0.5' video

Watch the 'New Dose-Response Analysis Package' video

Dose-Response Analysis Package

With PLA 3.0.5 we introduce a new add-on: The Dose-Response Analysis Package provides a range of additional biostatistical methods for immunoassays, ELISA, and more. It supports you in investigating equivalence for calibration curves and it provides enhanced data processing and analysis. New document reports and dashboards add to its value and usability.

Biostatistical methods

The biostatistical methods of the new package include :

Equivalence margin development

The package features several equivalence test and development options for calibration curves. You can employ equivalence and point estimate tests for parameter estimates and ANOVA terms. And you can use your historic assay runs to develop acceptance criteria. The package provides test strategy development, visualizations, and simulations. Read more...

Response data processing and subgroup analysis

The new package also features enhanced response data processing. You can adjust and normalize data either by a fixed value or by another assay element. Use these features, for example, to subtract the absorbance of blank wells or to divide response values by the mean absorbance of maximum binding wells. You can also employ transformations–logarithmic, square, and square-root. Apply adjustments, normalizations, and transformations to all samples, a specific sample, or to all test or control samples. You can apply adjustments and normalizations to specific plates as well. Moreover, you can average your replicates. To give you full control over data processing, you can employ several adjustment and normalization steps and you can adjust the sequence of response data processing steps to your needs.

With the new package, you can define analysis subgroups suitable to your experiment. Subgroups are available for both, single- and multi-dose samples. Use this feature, for example, to group samples in spike-and-recovery analysis or assay optimization. Statistics for interpolated results and dose-response curve characterization include averages, standard deviations, coefficient of variations, and recovery rates. Visualize results in overlay plots.

Document reports and dashboards

New document reports and dashboards further add to the package's value and usability. The dashboards display key attributes of document definitions and calculation results and visualize results in new data plots. The revised design of both reports and dashboards provides greater lucidity with a fresh and modern look, clear, uniformly applied layout, and a uniform color scheme in line with editor. Read more...

Always up to date with PLA 3.0

PLA 3.0.5 always keeps you informed about new extensions and developments. You can easily customize your work environment to get the most out of your installation.

The new Add-on management enables you to benefit from new extensions and developments. Stay informed on new releases and updates such as document packages and data acquisition modules. The Add-on management provides you with a list that is always up to date and puts all suitable add-ons at your fingertips. Just click once to start the add-on download and installation.

Now you can easily extend your work environment with new features. To evaluate them, simply try and use our latest products and integrated tools. You can request add-on trials and licenses with a single mouse click and activate and deactivate them just as easily. We provide demo data in the same location.

The add-on management also provides options to easily install and work with several add-on versions. Simply activate and try the newest add-on versions, or switch to a legacy version to run your legacy assays. You can update to PLA 3.0.5 to benefit from its innovations and still work with add-on versions that have already been validated in your environment.

The new dashboard keeps you informed about new developments and events around PLA 3.0.5. It also provides information on the database and can provide information posted by your organization. Last but not least, it displays your license and support status and enables all users to get quick access to help and support.

Usability and performance improvements

Customers who already work with PLA will notice numerous improvements that enhance performance and usability. Our efforts to improve your experience with PLA have streamlined workflows and eliminated redundant tasks.

When you develop a new assay document, PLA 3.0.5 uses the information you provide to automatically set up the data table. When you work with a plate layout, for example, PLA 3.0.5 now arranges the data table to match your layout as you develop the new assay document. In addition, PLA 3.0.5 enables you to easily adjust your data table to employ alternate plate layouts, accommodate data acquisition, or correct assignment errors.

Other improvements in PLA 3.0.5 further enhance the user experience:

  • A faster editor and overall performance improvements
  • The platform capabilities have been enhanced and now uses a 64-bit software platform.
  • Users who create many elements profit of the new feature to create up to 99 samples and other document elements at a time with just three mouse clicks.

Feature overview

Our new PLA 3.0.5 features.

Dose-Response Analysis Package
  • Various biostatistical methods
    • Interpolation on calibration curves
    • Spike-and-recovery analysis
    • Linearity-of-dilution assessment
    • Effective-concentration calculation
    • Curve comparisons
  • Equivalence for calibration curves
    • Equivalence tests for calibration curves
      • Equivalence tests for parameter estimates
      • Point estimate tests for parameter estimates
      • ANOVA terms
    • Equivalence margin development for calibration curves
      • Use your historic assay runs to develop acceptance criteria for calibration curves
      • Test strategy development
      • Visualizations
      • Simulations
  • Enhanced response data processing
    • Data normalization and adjustment
      • Use these features, for example, to subtract the absorbance of blank wells or to divide response values by the mean absorbance of maximum binding wells.
    • Data transformation
      • Logarithmic transformation
      • Square transformation
      • Square root transformation
    • Average replicates
    • Adjust the sequence of response data processing steps to your needs / Adjust the sequence of data processing steps
  • Subgroup analysis
    • Define any subgroups in your experiment
      • Subgroups for single- and multi-dose samples
      • E.g.: spike-and-recovery analysis
      • E.g.: assay optimization
    • Subgroup statistics of interpolated results and Dose-response curve characterization
      • Averages
      • Standard deviations
      • Coefficient of variations
      • Recovery rate
      • Overlay plots
  • New reports and document dashboards
    • More informative document dashboards
      • Document definition (e.g.: assay and test system setup)
      • Calculation results (overview and in-depth information)
      • Graphically improved data plots
    • Revised design of reports and dashboards
      • Provides greater lucidity
      • Fresh and modern look
      • Clear, uniformly applied layout and design
      • Uniform color scheme in line with editors
New Add-on management in PLA 3.0
  • Benefit from extensions and new developments
    • Stay informed on new releases and updates - such as:
      • Document packages
      • Data acquisition modules
    • Have all available add-ons at your fingertips
  • Easily customize your work environment
    • Request add-on trials and licenses with a single mouse click
    • Activate and deactivate add-ons with a single mouse click
    • Import demo data
  • Easily install and work with several add-on versions
    • Simply activate a legacy version to run your legacy assays
    • Simply activate and try the newest add-on versions
    • Update to PLA 3.0.5 to benefit from its innovations and still work with add-on versions that have already been validated in your environment
New dashboard in PLA 3.0
  • Stay informed on
    • New developments around PLA 3.0.5
    • Events related to PLA 3.0.5
    • Information on the database
    • Information posted by your organization
    • Your license and support status
  • Quickly access help and support
Revised data table handling
  • Automatically sets up the data table as you develop a new assay document
  • Automatically arranges the data table to match your plate layout
  • Allows you to easily adjust your data table
    • Employ alternate plate layouts
    • Accommodate data acquisition
    • Correct assignment errors
Refined user experience
  • Faster editor, overall performance improvements
  • More capable, 64-bit software platform
  • New feature: just three mouse clicks to create up to 99 elements at a time