Dose-Response Analysis Package

A dose-response model describes the magnitude of the response of something to a stimulus/dose. You could use a dose-response curve to correlate an unknown specimen's activity to a known concentration. This could be used to determine the residual protein amount in biological therapeutics (and other ELISA assays) or to measure the amount of cell lysis in relationship to the concentration of viral solution. It also can be used in areas that need to identify the hazard potential.

^{Please note: The Dose-Response Analysis Package is not intended for relative potency calculations, as those are covered by the Biological Assay Package.}

For each method, we provide sample documents you can download when activating the Dose-Response Analysis Package add-on in PLA 3.0.5 or higher. Additional information about each sample document is provided in the document's Comment section.

• Effective-concentration calculation (EC50)
• Interpolation analysis
• Spike-and-recovery analysis

• Curve comparisons
• Equivalence margin development
• Linearity-of-dilution assessment